Performance Measures in Dose-Finding Experiments

In the first phase of pharmaceutical development, and assuming that the probability of positive response increases with dose, the main statistical goal is to estimate a percentile of the dose–response function for a given target value $\mathrm{\Gamma }$. We compare the Maximum Likelihood and centred isotonic regression estimators of the target dose and we discuss several performance criteria to assess inferential precision, the amount of toxicity exposure and the trade-off between them for a set of some exemplary adaptive designs. We compare these designs using graphical tools. Several scenarios are considered using simulation, including the use of several start-up rules, the change of slope of the dose-toxicity function at the target dose and also different theoretical models, as logistic, normal or skew-normal distribution functions.     

Going green,going clean: Lean‐green sustainability strategy and firm growth

Despite the widespread recognition of the paybacks of “going green” and “going clean,” limited research has focused on the impact of lean‐green strategy on firm growth. In this study, we contribute to strategy and environmental sustainability literatures by investigating the possibility that the influence on lean‐green strategy and firm growth is driven by different levels of industry competition, managerial power, and family ties. Using panel data from 732 firms in four major industrialized economies (the United States, Germany, France, and the United Kingdom), we found that lean‐green strategy positively relates to firm growth and this relationship is amplified at higher levels of competition, managerial power, and family ties. Theoretical and practical implications of the study are also discussed.     

Can proactive environmental strategy improve Multilatinas' level of internationalization? The moderating role of board independence

This paper explores the relationships between proactive environmental strategy (PES) and internationalization in emerging markets multinationals from Latin America (Multilatinas). Drawing on the resource‐based view and institutional theory and using a sample of 86 listed firms during the period 2013–2017, we find that Multilatinas with higher tiers of PES are associated with higher degrees of geographic international diversification. Because adopting PES is directly conditioned by institutional pressures to comply with stakeholders' regulations and expectations, Multilatinas that implement advanced PES will be able to achieve a higher level of international presence in foreign markets. Our results also reveal that board independence positively moderates the relationship between PES and geographic international diversification. Specifically, board independence provides Multilatinas with the opportunity to integrate valuable knowledge and expertise and thus to take advantage of implementing advanced PES to achieve even greater levels of internationalization. This study expands understanding of how environmental strategies influence internationalization of firms in the Latin American business context.     

Moving beyond the tensions in open environmental innovation towards a holistic perspective

This paper analyses factors determining open environmental innovation (EI) and explores the possibility of embracing their tensions to achieve integrated environmental strategic goals. Building on recent literature linking open innovation and EI, the study assumes open EI strategic goals as a multidimensional construct based on the “synergistic and interwoven nature” of four identified enabling factors, that is, partners, knowledge, benefits, and motivations. A fuzzy‐set qualitative comparative analysis (fsQCA) based on Boolean algebra is conducted to analyse a set of 186 European companies operating in the telecommunication and information and communication technology (ICT) service industries. Making important theoretical, managerial, and policy contributions, this paper offers insights into the key factors enabling open EI and the tensional relationships within and between them. In doing so, it captures the non‐linear effects among these factors and the strategic goals related to an open EI strategy. It also suggests how the paradox theory might help in addressing the tensional dilemma of open EI strategy.     

京沪高铁沧州西站客流特征及服务策略研究

京沪高铁的开通,促进了河北省沧州市与北京、天津、上海等国内一线城市的交流,对加快河北省经济发展具有重要意义。基于京沪高铁沧州西站客流调查数据,文章从旅客的基本情况、出行目的、费用来源、月均收入、出行方向等方面分析了沧州西站的客流结构特征,从旅客的出行次数、结伴人数、出行时间、返程时间和车站的位置、服务等方面分析了沧州西站的旅客出行特征。在此基础上,从开行方案、票制、票价、交通换乘、服务方式等方面提出提升沧州西站服务的策略建议。     

考虑零售商销售努力的双渠道供应链定价策略研究

随着电子商务市场的日益成熟,制造商建设线上直销渠道来适应新的商品销售环境成为趋势。制造商线上直销渠道的建立占领了部分原本属于线下零售渠道的市场份额,对线下零售渠道造成冲击。针对双渠道供应链中的竞争,将零售商销售努力行为考虑在内,通过构建博弈模型分别研究了在集中决策模式和分散决策模式下,制造商与零售商的定价策略。研究发现,在集中决策模式下,线下零售渠道与线上直销渠道之间的价格差异随着两个渠道潜在需求量之间差异的增大而增大,并且两个渠道的最优价格分别与其市场潜在需求成正比。在分散决策模式下,两个渠道的最优价格亦与潜在需求成正比,并且线下零售渠道的最优价格随零售商销售努力程度的增加而增加,线上直销渠道的最优价格随着零售商销售努力程度的增加而减少。     

中国自贸区战略实施的现状、效果、趋势及未来策略

随着全球经贸规则的加速重构,我国自贸协定的谈判和签署步伐明显加快,且签署协定的开放水平不断提升,协定实施对双边贸易也产生了显著的促进效果。未来,中国的自贸协定谈判将呈现出覆盖范围更广、开放层次更高、协定对象向重点国家和地区突破的态势。为了实现"形成覆盖全球的高标准自贸区网络"的目标,我国应通过积极参与构建超大型自贸区、将自贸区网络建设与"一带一路"倡议相结合、深化自身改革提供制度支撑、综合考量宏观收益开展自贸谈判、设计兼具稳定性和灵活性的自贸协定"范式"等策略来推进自贸区建设。     

一种嵌入式软件无线电频谱监测系统

为了降低研发成本，提高频谱系统的灵活性和缩短研制周期，提出了一种基于软件无线电的嵌入式频谱监测系统。首先研究了系统硬件平台组成和特点，在此基础上设计了一种灵活的软件定义系统架构；然后考虑到硬件平台自身性能的限制，重点研究了频率偏移校正、频谱扫描策略等关键技术，分别提出了基于GSM信号和温度传感器的频偏校正方法和基于相关性的扫频策略；最后通过具体实验，对系统性能进行验证与评估，结果表明所提出的频偏校正方法能够将绝对平均频偏控制在1.749×10-6以内，所设计的基于相关性的扫频策略对时变信号的频谱监测效果最好。     

企业青年人才培养的科学策略分析

随着社会经济的发展,企业所面临的市场竞争环境更加激烈,从本质上来说,企业之间的竞争即知识和人才的竞争。青年人才属于助推企业持续发展的重要资源,也是促进企业改革创新的中坚力量。基于此,企业必须要充分认识到青年人才培养的必要性,采取有效策略开展好此项工作。论文结合实际工作对此问题展开了探讨。     

Destruction and settlement norms as determinants of conflict: An evolutionary perspective

This paper studies conflict in a simple bargaining framework using an evolutionary game-theoretic approach. Our findings suggest that a player does not always regard the winning probability as an acceptable settlement rule. He accepts a division according to winning probability when the destruction caused to him in conflict is more than a threshold, which in turn depends on cost of conflict to the opponent and the size of the population. Further, our analysis shows that the norms with positive weight to disagreement payoff are effective against conflict, and incentivize peace. Contrary to the findings of extant studies carried out in finite population evolutionary game setting, the settlement possibility set is identical under both ESS and Nash equilibrium in our model with settlement norms.